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Scientific and Therapeutic Overview of Tranexamic Acid, Hemostatic Mechanisms, and Applications in Acute
Tranexamic acid is an antifibrinolytic agent widely used to reduce bleeding in trauma situations, surgical settings, dental procedures, gynecological conditions, and hereditary bleeding disorders. It functions by inhibiting plasminogen activation and stabilizing fibrin clots, thereby preventing excessive blood loss.
In emergency medicine, tranexamic acid is life-saving for patients suffering from traumatic injuries or postpartum hemorrhage. Its rapid administration significantly reduces mortality associated with uncontrolled bleeding. It is also used in orthopedic, cardiac, and spinal surgeries to minimize transfusion requirements and improve recovery outcomes.
Dermatology and aesthetic medicine increasingly utilize topical tranexamic acid to manage melasma, post-inflammatory hyperpigmentation, and other skin discoloration issues due to its impact on melanocyte pathways.
Pharmaceutical advancements have introduced multiple formulations, including oral tablets, injectables, topical solutions, and combination therapy products. Research continues to evaluate new indications, such as gastrointestinal bleeding and intracranial hemorrhage.
Because of its strong safety profile and versatility, tranexamic acid remains one…

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